Ketamine was first approved by the FDA for therapeutic use as an anesthetic.
Psychedelic Therapy for Root-Cause Healing
Welcome to InnerMost, a pioneering interventional psychotherapy clinic based in the heart of New York City.
We believe healing is more than symptom suppression. It's about reconnecting with yourself, processing what's been left unresolved, and accessing the capacity you already carry. At InnerMost, psychotherapy isn't an add-on to psychedelic care—it's the foundation.
As psychedelics enter the mainstream, InnerMost is committed to defining, implementing, and disseminating the highest standards in psychedelic-assisted therapy and integrative mental healthcare by bringing compassionate treatment, therapist training, and clinical research under one roof.
Accepted Insurance Providers
InnerMost Clinical Services
We combine advanced clinical practices with the deep insights of psychedelic-assisted therapy, traditional psychotherapy, somatic healing, breathwork, and other trauma-informed modalities. Your InnerMost care team will collaborate with you to create a highly personalized treatment plan, designed to meet you exactly where you are on your healing journey.
- Ketamine Therapy
- Spravato® for Depression
- Harm Reduction & Integration
- Psychotherapy
What is Ketamine Therapy?
Ketamine therapy combines ketamine treatment with therapeutic guidance to help you overcome entrenched patterns, process trauma, and rediscover purpose. At InnerMost, we view ketamine as a catalyst for change, supported by expert clinicians to ensure lasting results.
Why Ketamine?
Ketamine has been shown to reduce depressive symptoms within hours, with relief lasting up to two weeks after a single treatment. For many, conventional medications like antidepressants suppress symptoms without addressing the deeper root causes of suffering—up to 85% of individuals don’t respond to these treatments.
What is Spravato®?
Spravato® is the only FDA-approved monotherapy for treatment-resistant depression (TRD), and it is covered by most insurances. It can provide transformative relief from depression symptoms. In a Spravato® therapy session, a nasal spray form of ketamine (esketamine) is self-administered under the supervision of certified clinical staff. For those who have difficulty responding to other treatments like medication or therapy, Spravato® can have transformative effects and help patients break free from the cycle of depression.
Why Spravato®?
Spravato® has shown to be one of the most promising modalities for treatment-resistant depression (TRD) in patients with major depressive disorder (MDD) with suicidal thoughts or actions. Its flexible dosing schedule allows for both acute relief and long-term maintenance. Currently, Spravato is the only FDA-approved ketamine therapy accessible to patients and is covered by most insurances, making it a more affordable treatment option.
Important safety information about Spravato® can be found here.
What is Harm Reduction & Integration?
We are committed to helping individuals engage with psychedelics more safely and intentionally. Rather than judging or pathologizing use, harm reduction honors patient autonomy and focuses on minimizing risks and promoting well-being—through education, post-psychedelic experience support, and integration psychotherapy.
Why is it important?
A pragmatic approach acknowledges that people are using psychedelics in underground contexts, recreationally, and even legally while abroad, but don’t have a psychedelic informed aftercare program in place. Instead of abstaining from helping people, we acknowledge this use is happening and meet people where they are—regardless of what society thinks about their life choices.
What is Psychotherapy?
Our therapists provide a safe, supportive space to explore the patterns and stories that shape your life. Rooted in evidence-based, trauma-informed care, psychotherapy at InnerMost helps you build resilience, gain new perspectives, and create healthier ways of relating to yourself and others. While we don’t offer ongoing medication management, our focus is on fostering the conditions for deep, lasting healing. Our team is trained to incorporate modalities like IFS, AEDP, and Gestalt psychology.
Why is it important?
We recognize that not everyone wants to, nor should, begin with ketamine therapy. Ordinary-state psychotherapy offers a safe place to reconnect with your wholeness and create lasting change. For some, this may be all they need; for others, it can serve as a foundation before exploring ketamine or Spravato®.
Our Model
From training the next generation of therapists, to creating safe, supportive environments for deep inner work, InnerMost is redefining the future of mental healthcare, one person at a time.
Clinical Services
Our experienced clinicians offer both individual and group therapy, blending evidence-based practice with trauma-informed, psychedelic-assisted care for lasting change.
Research Trials
We lead and participate in groundbreaking clinical trials, giving clients early access to promising psychedelic therapies and shaping the future of mental health treatment.
Therapist Hub
We provide immersive practicum programs and ongoing supervision, supporting therapists and healthcare providers at every stage of their psychedelic therapy journey.
Community & Education
Join our events, workshops, and discussions to connect, learn, and grow with others passionate about advancing safe, effective, and ethical psychedelic care.
Meet our expert team guiding innovation in therapy
Our team blends expertise in clinical research and in compassionate care to advance the field of psychedelic-assisted therapy. Get to know the professionals dedicated to supporting your journey.
Casey Paleos, MD
Chief Medical Officer & Co-Founder
Daniel Tisman, LCSW
Director of Psychotherapy & Co-Founder
Amanda Vogel, PMHNP-BC
Psychiatric Nurse Practitioner & Clinical Nurse Manager
Cait Burke, PMHNP-BC
Psychiatric Nurse Practitioner
Jacob Perlson, MD
Physician
Miles Bukiet, LMSW
Director of Clinical Culture
Alex Belser, PhD
Senior Therapist
Liana Eisler
Care Coordinator
Events
Attend InnerMost’s group ketamine-assisted therapy experiences, a fireside chat speaker series in collaboration with Psychedelic Assembly, conference panel discussions featuring Dr. Casey Paleos, and more.
- Upcoming
- Past
January 29, 2026
InnerMost Mixer with Myriam Barthes: An Evening of Connection with Leaders Shaping the Future of Therapy
Facilitator
InnerMostOverview
Once a month, InnerMost hosts The InnerMost Mixer — a space for therapists, psychiatrists, researchers, and medical professionals to connect, learn, and share in community. This gathering brings together clinicians across disciplines who are engaged in or curious about psychedelic-assisted therapy and research. This month’s mixer features Myriam Barthes, Co-Founder & Chief Executive Officer at Journey Clinical — the leading telehealth platform expanding access to psychedelic-assisted psychotherapy.
View DetailsDecember 18, 2025
InnerMost Mixer with Alex Camargo, PsyD: An Evening of Connection with Leaders Shaping the Future of Therapy
Facilitator
InnerMostOverview
Once a month, InnerMost hosts The InnerMost Mixer — a space for therapists, psychiatrists, researchers, and medical professionals to connect, learn, and share in community. This gathering brings together clinicians across disciplines who are engaged in or curious about psychedelic-assisted therapy and research. This month’s mixer features Alex Camargo, PsyD — a New York–based psychologist whose work sits at the intersection of psychedelic therapy, psychodynamic practice, and attachment-based care.
View DetailsNovember 20, 2025
InnerMost Mixer with Diana Fosha, PhD: An Evening of Connection with Leaders Shaping the Future of Therapy
Facilitator
InnerMost and Diana Fosha, PhDOverview
Once a month, InnerMost hosts The InnerMost Mixer — a space for therapists, psychiatrists, researchers, and medical professionals to connect, learn, and share in community. This gathering brings together clinicians across disciplines who are engaged in or curious about psychedelic-assisted therapy and research. Diana Fosha, PhD, founder of the groundbreaking therapy modality, AEDP, will be co-hosting and offering a talk at the Nov 20th mixer.
View Details
November 13, 2025
Psychedelics 101: Bridging Science, Stories & the Power of Psychedelics
Facilitator
InnerMost and The Psychedelic AssemblyOverview
Join us for Psychedelics 101, a foundational panel discussion designed to unpack the world of psychedelics. Whether you’re curious, skeptical, or already engaged in the conversation, this event offers an accessible introduction to one of the most compelling topics in mental health and wellness today.
View DetailsNovember 7, 2025
The Psychedelic Assembly: Find the Others
Facilitator
The Psychedelic AssemblyOverview
Join us on November 7th for the next Find the Others: The Psychedelic Assembly’s beloved monthly community night. These magical evenings are low-pressure, casual and fun nights designed to help folks in the psychedelic community connect. Whether you’re a seasoned psychonaut, or just beginning to explore this world, all are welcome!
View DetailsOctober 30, 2025
Beyond the Journey—An Evening of Meditation
Facilitator
Suzy Baker & Miles BukietOverview
Beyond the Journey is a space for those on a path of personal growth—whether through meditation, therapy, or psychedelic experiences—to slow down and return to the wisdom within. Grounded in Buddhist-inspired meditation and informed by the insights of psychedelic care, this gathering invites you to deepen your self-awareness, cultivate compassion, and connect with a like-minded community. This is not a psychedelic event—no substances will be taken.
View DetailsOctober 8, 2025
An Evening for Psychedelic Integration in NYC
Facilitator
Psychedelic AssemblyOverview
Join the Psychedelic Assembly at an Evening for Integration in NYC, a gently held evening of reflection, connection, and support. With a rich background in Psychedelic Integration, Yoga, Meditation, End-of-Life Care, and Religious Studies, Suzy Baker holds space with grounded presence and deep care. Her work is informed by a wide range of spiritual traditions bringing a blend of helpful coaching and soulful friendship to each session— a place to process experiences, explore life transitions, and reconnect with your inner wisdom.
View DetailsOctober 3, 2025
Psychedelic Assembly: Find the Others
Facilitator
Psychedelic AssemblyOverview
Join us on October 3rd for the next Find the Others: Psychedelic Assembly’s beloved monthly community night. These magical evenings are low-pressure, casual and fun nights designed to help folks in the psychedelic community connect. Whether you’re a seasoned psychonaut, or just beginning to explore this world, all are welcome!
View DetailsSeptember 23, 2025
Psychedelic Assembly: Psychedelics for Everyone?
Facilitator
The Psychedelic AssemblyOverview
Join us for a fireside conversation with author Joe Dolce and comedian Sarah Rose Siskind, on Joe’s new handbook “Modern Psychedelic.” There’s a lot of hope, a lot of hype and a lot of marketing in the world of psychedelics these days. Whether you’re an infrequent flier or an experienced traveler, how much do you really know about how to use these powerful molecules for more health, more healing, or more fun?
View DetailsJune 18, 2025
Addressing Myths and Misconceptions about MDMA Assisted Therapy
Facilitator
Psychedelic Science 2025Overview
As MDMA-assisted therapy moved toward regulatory approval in 2024, misinformation and oversimplifications shaped public, professional, and regulatory discourse on the topic. Today, misunderstandings about the form of MDMA-assisted therapy provided in the Phase 3 trials persist. This panel brings together leading clinician-researchers to address key myths and misconceptions about the content, process, and safety of this treatment.
View DetailsMarch 7, 2025
The Future of PTSD Treatment: With or Without MDMA
Facilitator
SXSW 2025Overview
In today’s mental health crisis, nearly 1 in 10 Americans will suffer from PTSD—it’s an uncertain time for veterans and others suffering given the FDA’s resistance to MDMA legalization. However, MDMA is not the only wonder drug or treatment for PTSD. The psychedelic therapy paradigm, supporting people to get to the root of trauma, is a common thread with different modalities and protocols, each with unique approaches and outcomes. From MDMA, ketamine, and ibogaine to integration therapy, experts share everything you need to know about these groundbreaking options saving lives today.
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