Spravato® Therapy in Manhattan, NYC
InnerMost offers Spravato therapy in Manhattan rooted in one core belief: medicine works best when it's paired with skilled therapeutic support. Spravato (esketamine) is the only FDA-approved intranasal ketamine treatment for treatment-resistant depression, and it's covered by most major insurance plans. At our Manhattan clinic, every Spravato treatment pathway is built around preparation, integration, and the expertise of our board-certified physicians and licensed psychotherapists. If you've tried antidepressants without lasting relief, Spravato® may be the breakthrough you've been looking for.
What is Spravato Therapy?
Spravato is the brand name for esketamine, a nasal spray form of ketamine developed specifically for people with treatment-resistant depression (TRD) and major depressive disorder (MDD) with acute suicidal ideation or behavior. It is the only FDA-approved ketamine therapy currently on the market, and the only one covered by most major insurance plans, making it a meaningful option for patients who need effective care but have felt priced out of other treatments.
In a Spravato session, you self-administer the nasal spray under the direct supervision of certified clinical staff. The medication works by blocking NMDA receptors and triggering a cascade of glutamate activity in the brain, promoting the formation of new neural connections. Unlike traditional antidepressants that can take weeks to produce results, Spravato can reduce depressive symptoms within hours to days. For people with treatment-resistant depression, that speed can be genuinely life-changing.
At InnerMost, Spravato is not just administered, it is integrated. We combine evidence-based clinical care with licensed psychotherapy, so the relief Spravato provides becomes a foundation for lasting change, not a temporary reprieve.
- Spravato is the only FDA-approved monotherapy for treatment-resistant depression (TRD) and is covered by most major insurance plans.
- Unlike traditional antidepressants, Spravato can reduce depressive symptoms within hours to days, not weeks.
- Spravato has been rigorously studied in clinical trials and is the most extensively validated ketamine therapy available.
Why Choose InnerMost for Spravato Therapy in Manhattan?
Manhattan has options for Spravato therapy. What sets InnerMost apart is what happens around the treatment itself: the preparation before, the therapeutic presence during, and the integration after every dosing session. We believe Spravato without a strong therapeutic framework is a missed opportunity. Here is what makes InnerMost different:
01
Integration is built in, not bolted on.
At most Spravato providers, you self-administer the nasal spray, wait out the monitoring period, and go home. At InnerMost, every Spravato treatment pathway includes preparation and integration sessions with a licensed therapist. These aren’t optional add-ons. They are core to how we practice, because we know the integration window is where insights become lasting change.
02
Three pathways tailored to your needs.
We offer three distinct Spravato treatment formats, from standalone supervised sessions to full psychotherapy integration, so you receive care that is calibrated to the severity of your symptoms and the depth of work you want to do. Your InnerMost care team will help you determine the right fit during your initial consultation.
03
A space designed for healing.
Our Manhattan center was intentionally designed with healing in mind. From the color palette and materials to the layout of each treatment room, every detail has been considered with your comfort and inner experience in mind. When you arrive for your Spravato session, you won’t feel like you’re in a clinical waiting room. Set and setting matter, even in FDA-approved ketamine therapy, and we’ve built a space that honors that.
04
Clinical research leadership.
InnerMost leads and participates in groundbreaking clinical trials in psychedelic-assisted therapy. Our team includes active researchers and senior clinicians who are shaping the future of this field alongside practicing in it. When you receive Spravato at InnerMost, you’re in the care of people at the forefront.
05
Affirming care for every patient.
Our entire team is trained in trauma-informed, culturally affirming care. We offer specialized programs for LGBTQIA+ clinicians and patients, and we believe effective, compassionate mental health care should be available to everyone.
06
Most insurance accepted.
Spravato is covered by most major insurance plans, including Aetna, Cigna, UnitedHealthcare, Empire BlueCross, Medicare, and Fidelis. Effective, evidence-based Spravato therapy in Manhattan is more accessible than most people expect.
Who We Can Help
Spravato is FDA-approved for adults diagnosed with the following conditions:
- Treatment-Resistant Depression (TRD): patients who have not responded to two or more antidepressant treatments
- Major Depressive Disorder (MDD) with Acute Suicidal Ideation or Behavior
Many of our Spravato patients in Manhattan have tried antidepressants, therapy, or both, sometimes for years, without finding lasting relief. If that describes your experience, you are exactly who we are here to serve. Spravato is not a last resort; it is a different path, one that works through an entirely different mechanism than conventional antidepressants and can produce results that other treatments simply haven’t.
During your initial assessment, our clinical team will review your full history to determine whether Spravato is an appropriate treatment and which of our three pathways is the right fit for you.
How Spravato Works: Key Benefits
Spravato’s impact operates on multiple levels: neurological, psychological, and relational. Here’s what the research and clinical experience show:
Rapid relief.
Spravato can reduce depressive symptoms within hours to days of the first session. For people with treatment-resistant depression who have spent months or years trying to find something that works, that speed is significant. Unlike SSRIs and SNRIs, which rely on slow serotonin modulation, Spravato targets the glutamate system directly, producing faster, more pronounced neurological changes.
Neurological restoration.
Chronic depression erodes synaptic connections in critical brain regions. Spravato works by blocking NMDA receptors and triggering a surge of glutamate activity that promotes neuroplasticity: the brain’s ability to form new connections and patterns. This window of heightened adaptability is what makes therapeutic support so valuable alongside Spravato treatment. New ways of thinking and relating become genuinely accessible.
Sustained change through integration.
Spravato opens a door. Integration therapy is how you walk through it. At InnerMost, every Spravato session is paired with integration work: a dedicated therapy session in the days following each dosing session, where you and your therapist process what arose and translate it into your daily life. Many of our patients describe it as feeling like something that was stuck has finally started to move, and the integration work is what helps that movement last.
Insurance-covered access.
Because Spravato is FDA-approved, it is covered by most major insurance plans, making it one of the most financially accessible ketamine therapies available in Manhattan. Our team will work with you to verify your benefits and navigate the process from day one.
Three Ways to Access Spravato Therapy at InnerMost
We recognize that no two people arrive at Spravato® therapy the same way. Some are seeking rapid relief from severe symptoms. Others want to go deeper into the therapeutic process. Our three Spravato therapy pathways are designed to meet you exactly where you are. Your InnerMost care team will help you determine the right fit during your initial consultation.
Spravato Intranasal With Integration (S-KIWI)
Spravato Intranasal Treatment (S-KIT)
S-KAP Spravato AssistedPsychotherapy
Treatment sessions under medical supervision
Psychotherapist is in the room with you before & after the administration and monitoring
Treatment sessions under medical supervision, with an InnerMost psychotherapist in the room with you before & after the administration and monitoring
Private, beautiful room
Private, beautiful room
Private, beautiful room
Preparatory sessions and weekly integration sessions with your InnerMost therapist
Must be enrolled in weekly psychotherapy with your own outside psychotherapist, in collaboration with our prescriber
Preparatory sessions and weekly integration sessions with your InnerMost therapist
Spravato treatment is covered by insurance, while psychotherapy may or may not be covered
Spravato treatment is covered by insurance
Spravato treatment is covered by insurance, while psychotherapy may or may not be covered
Best suited for rapid relief in case of higher intensity symptoms
For higher intensity symptoms or as a support to your current psychotherapy work
To go deeper with psychotherapy
What to Expect: Your Spravato Therapy Journey at InnerMost
At InnerMost, your Spravato journey begins with compassionate care and thoughtful preparation. Each treatment session takes place in a private, supportive setting in our Manhattan center, followed by integration to help you weave insights into lasting change. Our team is with you every step of the way.
01
Medical & Psychological Assessment
You’ll begin by meeting with an InnerMost clinician for a 1-hour Medical Consultation, typically via telehealth for your convenience. This session covers a comprehensive medical and psychiatric assessment to review your history and confirm that Spravato is an appropriate treatment. You’ll then meet with an InnerMost psychotherapist for a 50-minute Therapy Consultation to determine which Spravato pathway is the best fit and begin laying the groundwork for your care.
02
Preparation
Once you’re confirmed eligible, your next step is a Preparation session with your own therapist or an InnerMost therapist. This is your opportunity to set intentions, build safety, and develop a rapport before your first dosing session. We recommend at least one preparation session, with the option to schedule additional sessions in the week leading up to your initial Spravato treatment. Preparation sessions typically run just under an hour.
03
Spravato Session
Each Spravato session begins with a check-in and vital signs. You will then self-administer the nasal spray under the supervision of a certified clinician. Depending on your treatment pathway, an InnerMost therapist may be in the room with you before and after administration to help you navigate what arises. The full session, including monitoring and recovery time, lasts approximately 120 minutes. You’ll have an optional eye mask, blankets, and ambient music in a serene, private room designed to support your inner experience. Vitals are measured again at the close of each session.
04
Integration
Within a few days of your dosing session, you’ll meet with your therapist for a 1-hour integration session to discuss your Spravato experience and any shifts in perspective. This is where the real work of lasting change happens: processing insights, translating the experience into your daily life, and deepening the therapeutic process. Integration sessions can take place with your own psychotherapist or with an InnerMost therapist, and can include practices like journaling, meditation, somatic awareness, or mindfulness techniques.
05
Follow-Up
Spravato is typically administered twice weekly for the first four weeks, then weekly or every other week for ongoing maintenance. Following your integration session, you’ll check in with the InnerMost team to discuss how things are going and assess the need for ongoing treatment. Your plan always evolves with you.
A Space Designed for Your Healing
Location matters in Spravato therapy. At InnerMost, our Manhattan center is an intentional part of the treatment, not an afterthought. Our space was designed to support the nervous system and to create the sense of safety, calm, and containment that allows deep inner work to unfold.
Even within an FDA-approved clinical treatment like Spravato, set and setting matter. Set refers to the mindset you bring into a session; setting refers to the physical environment around you. We take both seriously. From the materials and color palette of each treatment room to the recovery lounge where you rest after your session, every detail has been considered with your healing in mind.
Our center is located at 137 East 25th Street, 11th Floor, in the Gramercy neighborhood of Manhattan, easily accessible from Midtown, Flatiron, Gramercy, Chelsea, and the surrounding area.
Pricing & Insurance for Spravato Therapy in Manhattan
We believe financial considerations shouldn’t stand between you and effective mental health care. Here’s what you need to know about the cost of Spravato® therapy at InnerMost in NYC:
Spravato (esketamine): covered by most insurance.
Spravato® is FDA-approved and covered by most major insurance plans, including Aetna, Cigna, UnitedHealthcare, Empire BlueCross, Medicare, and Fidelis. For eligible patients, it is the most cost-accessible ketamine therapy option available in Manhattan. Our team will work with you from the start to verify your benefits and navigate the insurance process.
Psychotherapy sessions: coverage varies.
Preparatory and integration therapy sessions may or may not be covered by your plan depending on your specific benefits. We’ll work with you to understand your options and make care as accessible as possible. Please reach out to our team for current pricing and to discuss what may be available under your plan.
Frequently Asked Questions About Spravato Therapy in Manhattan
Is Spravato legal in Manhattan?
Yes. Spravato (esketamine) is FDA-approved for clinical use and is fully legal to administer in medical settings in New York. At InnerMost, Spravato is prescribed and administered by licensed medical providers in full compliance with New York state regulations. It is specifically approved for treatment-resistant depression and major depressive disorder with acute suicidal ideation or behavior.
How is Spravato different from IV ketamine?
Spravato uses esketamine, a specific form of ketamine delivered as a nasal spray and self-administered under clinical supervision. IV ketamine uses the full ketamine molecule, delivered intravenously. Both work through the glutamate system, but they differ in their pharmacological profile, dosing schedule, and most significantly, their insurance status. Spravato is FDA-approved and covered by most insurance. IV ketamine is not typically covered. During your initial consultation, our team will help you determine which option is best suited to your clinical needs.
How do I know which Spravato pathway is right for me?
Your first step is an intake consultation with one of our clinicians and therapists. During this visit, we’ll review your medical and psychological history, discuss your current challenges, and explore whether Spravato is the right fit. If it is, we’ll help you determine whether S-KIWI, S-KIT, or S-KAP best suits your needs. You don’t need to figure this out before you call.
What makes InnerMost different from other Spravato providers in NYC?
At InnerMost, Spravato therapy is always grounded in a therapeutic framework. Every treatment pathway includes preparation and integration sessions with a licensed psychotherapist. These are not optional add-ons; they are a core part of how we practice. We also bring together clinical services, active research trials, and a therapist training hub under one roof, creating an environment where the standards of care are continually shaped and refined by people at the forefront of the field.
Does InnerMost accept insurance for Spravato therapy?
Yes. Spravato is covered by most major insurance plans, including Aetna, Cigna, UnitedHealthcare, Empire BlueCross, Medicare, and Fidelis. Psychotherapy sessions may or may not be covered depending on your plan. Our team will help you verify your benefits and navigate the process.
How many Spravato sessions will I need?
Spravato is typically administered twice weekly for the first four weeks (the acute phase), then weekly or every other week for ongoing maintenance. The exact number of sessions depends on your condition, your response to treatment, and the pathway you and your care team select. Your InnerMost team will create a plan tailored to you and revisit it as you progress.
Is Spravato safe?
Spravato has been rigorously studied in clinical trials and is specifically FDA-approved for treatment-resistant depression, meaning it has met the agency’s standards for safety and efficacy. In a supervised clinical setting like InnerMost, the risk of adverse events is low. Our clinicians conduct a thorough medical and psychological assessment before beginning treatment, and vital signs are monitored throughout and at the close of each session. You are never left alone during a Spravato session.
How do I get to InnerMost from around Manhattan?
Our center is located at 137 East 25th Street, 11th Floor, New York, NY 10010, in the Gramercy neighborhood. We’re easily accessible from Midtown, Flatiron, Gramercy, Chelsea, and the East Village. The 6 train stops at 28th Street, and the N/R/W stops at 28th Street on Broadway, both within walking distance.
What ages does InnerMost treat?
We currently offer Spravato therapy for adults ages 18 and over.
Ready to Start Your Journey?
If you’re in Manhattan or anywhere in New York City and wondering whether Spravato therapy is right for you, we’d love to hear from you. Schedule a free discovery call with an InnerMost care coordinator. It’s a chance to explore your options, ask questions, and see if our approach feels like the right fit. There’s no obligation and no pressure. We’re here to listen and offer guidance.
Disclaimer: Our clinicians are only licensed to deliver services in-person or via telehealth in the state of New York.
